In this work we showed that simultaneous inhibition of HSPA isoforms (Fig. 4B), in contrast to both single paralog-specific (Figs 2C–F, S1C–F) and double knockdown (Fig. 3B–D) of HSPA1 and HSPA2 isoforms, evoked significant antiproliferative effect on human NSCLC cells. This evidence concerns the gene HSPA1A and non-small cell lung carcinoma.