Although this response has not been systematically studied, it seems noteworthy that inhibition of HSPA by 2-phenylethynesulfonamide (PES, pifithrin-μ) increased the toxic effect of CDDP (and also docetaxel and gemcitabine), in combination with HSPC inhibitor 17-AGG in bladder cancer cells62. The gene discussed is PSMA7; the disease is urinary bladder cancer.