HBE1 and Schnyder corneal dystrophy: Because HBB NIPT is an amplicon-based NGS assay, the ability to detect fetal inheritance of this variant (rs713040) is identical to that of SCD or any other pathogenic variants that are found in the target region of exon 1 (e.g., HbS; HbC; HbE; IVS1,1; IVS1,5).