IDH1 and acute myeloid leukemia: Hot-spot mutations of the metabolic enzyme IDH1/2 (isocitrate dehydrogenases 1 and 2) are observed in several types of cancers including secondary glioblastomas (GBMs)12, acute myeloid leukemia (AML)13, chondrosarcoma14–16 and cholangiocarcinoma17,18.