Studies show that the expression of Timp2 (tissue inhibitor of metalloproteinase 2), Timp3 (tissue inhibitor of metalloproteinase 3) and Adamts5 (a disintegrin-like and metalloproteinase with thrombospondin type 1 motif, 5) reduce angiogenesis in melanoma cells24–26. Here, ADAMTS5 is linked to melanoma.