A recent study suggested that PGRN has anti-inflammatory effects in the context of wound repair, autoimmune disease (psoriasis vulgaris), central nerve system damage, arthritis, and acute ischemia-reperfusion injury5,26–29, while PGRN dysregulation has been shown to be dysregulated in obesity, insulin resistance, type 2 diabetes mellitus, dyslipidemia, and renal disease30–33. This evidence concerns the gene GRN and arthritic joint disease.