In the past our group showed that most of the typical human tumor-associated macrophage (TAM) markers such as Stabilin-1, CD163 and Lyve-1 need the combined stimulation with macrophage colony-stimulating factor (M-CSF), dexamethasone and interleukin 4 (IL-4) (MDI) for their induction in human peripheral blood monocytes (pBM) in vitro. The gene discussed is IL4; the disease is neoplasm.