A member of the BTP family, BMP1, has been recently shown to be associated with tumor metastasis and found to be secreted by CAFs in colorectal cancer [1]; downregulation of BMP1 by microRNA miR-194 reduces lung metastasis, probably by decreasing TGF-β activation [53], while BMP1 expression predicts poor progression in clear cell renal cell carcinoma patients [54]. Here, BMP1 is linked to clear cell renal carcinoma.