It was found that in acute lymphoblastic leukemia cell line MOLT-4 and mantle cell lymphoma JeKo-1, the downregulation of LSD1 by siRNA results in blocking the cell cycle in the G0/G1 phase, an increased expression of p21, and an induction of apoptosis [44]. The gene discussed is CDKN1A; the disease is acute lymphoblastic leukemia.