Early studies suggested that TAGLN was a tumor suppressor gene in various cancers, while some cancers possessed the oncogenic characteristic of TAGLN. The overexpression of TAGLN potentially contributed to the progression and metastasis of colorectal cancer; meanwhile, high levels of TAGLN related to a poor prognosis of colon cancer in vivo [14,15]. The gene discussed is TAGLN; the disease is colonic neoplasm.