Following this, Feng et al. [75] reported that the upregulation of SIRT6 expression was required for transforming growth factor (TGF)-β1 and H2O2⁄HOCl reactive oxygen species (ROS) to promote the tumorigenicity of hepatocellular carcinoma (HCC) cells. This evidence concerns the gene TGFB1 and hepatocellular carcinoma.