In addition, Small et al. (2000) demonstrated that a single copy of the ApoE-4 allele is also associated with lower cerebral cortical metabolism (e.g., the parietal, temporal, and posterior cingulate areas) [4], which could predict cognitive decline after 2 years of longitudinal follow-up since patients with AD have been demonstrated to show extensive early deposition of neuropathological lesions in these cerebral areas [77]. Here, APOE is linked to Alzheimer disease.