To identify the major AGE-modified proteins under enhanced carbonyl stress, the AGE-modified proteins were enriched from cultured GLO1 (−/−) iPS cells by anion-exchange chromatography (Mono Q; GE Healthcare), and the fraction containing the highly CML-modified 60-kD proteins was identified by immunoblotting with anti-CML antibody. Here, GLO1 is linked to chronic myelogenous leukemia, BCR-ABL1 positive.