Because human-induced pluripotent stem (iPS) cell technologies have enabled an in vitro recapitulation of the neuropsychiatric disease pathogenesis (Balan et al, 2018), we set out to analyze iPS cells with GLO1 disruption as a cellular model to uncover the missing link between enhanced carbonyl stress and the development of schizophrenia, at a very early developmental stage. This evidence concerns the gene GLO1 and schizophrenia.