Furthermore, the recent discovery for the role of mTOR signaling in the pathogenesis of neuropsychiatric disorders through altered proteostasis (Hui et al, 2019) and the regulation of the DPYSL2 expression by mTOR (Liu et al, 2014; Pham et al, 2016) points to a possible additional role of dysregulated mTOR signaling in schizophrenia pathogenesis, through CRMP2-mediated aggregate formation. The gene discussed is DPYSL2; the disease is schizophrenia.