DICER1 and intrahepatic cholangiocarcinoma: Given that the H3K9me3/SUV39H1/HP1α/Dnmts complex is crucial for chromatin modifications of gene expression in hepatocarcinoma (HCC) [33], our data suggest that CyclinD1 may interact with epigenetic regulators, such as H3K9me3, to inhibit Dicer expression in ICC cells.