Interestingly, induction of Dicer over-expression reduced the levels of CyclinD1 expression in HuccT-1 and HCCC9810 cells, but not in HIBEpic cells, suggesting that Dicer may indirectly inhibit CyclinD1 expression in ICC cells (Fig. 2e and f). The gene discussed is DICER1; the disease is intrahepatic cholangiocarcinoma.