KMT2A and acute myeloid leukemia: To further understand the mechanism of action underlying the synergistic interaction between chidamide and MI-3 in AML-carrying MLL-rearrangement, the RNAseq assay was then performed to profile genome-wide gene expression in MOLM-13 cells after treated with chidamide and MI-3 alone or in combination (see Additional file 2: Table S2 for a list of all genes).