(1), showing that changes in the maximum effect of pembrolizumab on the activation of CD8+ T cells, \documentclass[12pt]{minimal}\usepackage{amsmath}\usepackage{wasysym}\usepackage{amsfonts}\usepackage{amssymb}\usepackage{amsbsy}\usepackage{mathrsfs}\usepackage{upgreek}\setlength{\oddsidemargin}{-69pt}\begin{document}$$a_{pem}$$\end{document}apem, affect the balance between tumor growth rate and the efficacy of the immune system. The gene discussed is CD8A; the disease is neoplasm.