The aim of this study was therefore to investigate the potential prognostic impact of tumor cell expression of hormone receptors in terms of local relapse-free survival (LRFS), distant metastasis-free survival (DMFS), and overall survival (OS) in patients who received curative resection for non-metastatic CRC and further to validate the prognostic role in two independent CRC datasets. Here, NR4A1 is linked to colorectal carcinoma.