ESR1 and colorectal carcinoma: On univariate analysis, low and high ER-α expression demonstrated significant differences in the 5-year OS (89% vs. 47%, p < 0.001), LRFS (95% vs. 71%, p < 0.001) and DMFS (95% vs. 70%, p < 0.001) (Fig. 1, Tables 2 and 3) rates of CRC patients, while PR were not found to be significantly associated with improved 5-year OS, LRFS and DMFS rates (Additional file 1: Table S1).