Regarding obesity, green tea extract is a well-tolerated natural product for the management of obesity by reducing fat digestion through marked inhibition of digestive lipases, such as gastric and pancreatic lipases, especially by saponins, which lead to altered lipid emulsification in gastric or duodenal media [140]. The gene discussed is PNLIP; the disease is obesity due to melanocortin 4 receptor deficiency.