In breast cancer cells, other oncomiRs, miR-1297 and miR-103b, are also responsible for breast tumorigenesis by directly targeting PTEN [151,152], whereas miR-221 and miR-19a-3p also displayed potent oncogenic roles through negative regulation of PTEN in lung and hepatocellular carcinoma, respectively [153,154]. The gene discussed is PTEN; the disease is breast cancer.