HMGCR and neoplasm: Molecular studies confirmed the tumorigenic role of miR-331 is due to its association with gene targets related to metastatic processes including HER2, HOTAIR, E2F1, DOHH, and PHLPP. In addition, the role of miR-195, a known tumor suppressor, has also been validated by confirmation of its target genes, FASN, HMGCR, ACACA, and CYP27B1, which are implicated in tumor growth, EMT, invasion, and metastasis [89].