CDKN1A and breast carcinoma: Huang et al. revealed that the overexpression of miR-26a-5p with miRNA mimic transfection induced proliferative growth of breast cancer cells, with a marked decreased in the expression levels of cell cycle regulators cyclin D1, CDK4, and CDK6, and increased the expression of p21, p27, and p53 tumor suppressor protein [67].