Interestingly, after the addition of beta-glucan to animal feed, we noticed a significant reduction in the expression of Il10ra, Il16, Il21, Il2rg, Il5ra, Lta, Ltb, Osm, Tnf, Tnfsf11, and Tnfsf14 in rats with colitis, with a stronger protective effect demonstrated by low molecular weight beta-glucan (CβGl+). Here, IL5RA is linked to colitis.