The identified correlation between t-PA level, WMH severity, and the size of perivascular spaces in patients with SVD—MRI signs of SVD associated with endothelial dysfunction, increased BBB permeability, and immune-mediated brain damage—correspond to the previously, experimentally established participation of t-PA in these pathological processes and their importance in the progress of SVD and its clinical manifestations. The gene discussed is PLAT; the disease is snowflake vitreoretinal degeneration.