In order to correctly administer immunotherapy, the National Comprehensive Cancer Network (NCCN) and the College of American Pathologists (CAP), the International Association for the Study of Lung Cancer (IASLC), and the Association for Molecular Pathology (AMP) guidelines strongly recommended that the expression of PD-L1 protein should be tested in patients [38,39]. The gene discussed is CD274; the disease is lung carcinoma.