According to ASCO guidelines, to date, three different drugs are presently FDA approved and recommended in clinical practice for the treatment of metastatic NSCLC: nivolumab, pembrolizumab and atezolizumab; specifically, pembrolizumab is recommended for monotherapy, and in the first line setting for patients with nonsquamous or squamous NSCLC without driver gene mutations (EGFR/ALK) and with a high PD-L1 expression (tumor proportion score (TPS) ≥ 50%). The gene discussed is CD274; the disease is non-small cell lung carcinoma.