RHOA and coronary artery disorder: On the other hand, it is noteworthy that recent genome-wide association studies (GWAS) found a significant correlation between the risk of coronary artery disease (CAD) and either a variant of CCM2 [31] or mutations of RhoA GTPase [32], suggesting that either CCM proteins or associated signaling pathways, such as the established RhoA/ROCK pathway [13], may influence the risk of CAD.