CD8A and osteoarthritis, knee: When considering the total numbers of cells, CD14+ macrophages (knee OA: 116.1 ± 48.42 cells/mg; hip OA: 29.45 ± 15.88 cells/mg, p = 0.0293) were significantly increased in knee OA, and CD8+ cytotoxic T cells showed a trend for increase in knee OA (knee OA: 7.88 ± 2.67 cells/mg; hip OA: 2.59 ± 1.83 cells/mg, p = 0.0863) (Figure 1D), suggesting that hip and knee osteoarthritis are distinct with regard to the inflammatory processes that take place in the synovial membrane.