Curcumin has been reported to abolish CAF (cancer-associated fibroblast)-induced invasion and EMT (epithelial–mesenchymal transition), and inhibited ROS production and CXCR4 and IL-6 receptor expression through inhibiting MAOA/mTOR/HIF-1α (monoamine oxidase A/mammalian target of rapamycin/hypoxia-inducible factor-1α) signaling, thereby supporting the therapeutic effect of curcumin in prostate cancer [103]. This evidence concerns the gene MAOA and Familial prostate cancer.