In the DELIGHT trial [90], the addition of saxagliptin, a DPP-4 inhibitor, to the SGLT2 inhibitor dapagliflozin increased the renal benefit (albuminuria) observed with dapagliflozin in patients with type 2 diabetes and moderate to severe CKD on stable doses of RAS inhibitor. The gene discussed is SLC5A2; the disease is type 2 diabetes mellitus.