In a post hoc analysis of Rivaroxaban-Once Daily, Oral, Direct Factor Xa Inhibition Compared with Vitamin K Antagonism for Prevention of Stroke and Embolism Trial in Atrial Fibrillation (ROCKET AF) trial, patients with aortic stenosis had an increased risk of stroke, systemic embolism, and major bleeding compared to patients with other VHDs or without VHDs [31]. Here, F10 is linked to aortic stenosis.