HLA-C and psoriasis: This region contains several candidate genes, including HLA-C (associated variant HLA-Cw6 [HLA-C*06:02]; an MHC class I protein), CDSN (associated variant allele 5; corneodesmin, a protein expressed in the upper epidermis) [139], and CCHCR1 (associated variant WWCC; a widely expressed protein that is overexpressed in psoriasis) [140].