TYK2 and psoriasis: Other psoriasis susceptibility loci include PSORS2 on chromosome 17q24–q25, which spans the gene for caspase recruitment domain-containing protein 14 (CARD14), a scaffolding protein involved triggering NF-κB activation [145,146]; PSORS4 on chromosome 1q which spans the epidermal differentiation complex [147]; PSORS6 on chromosome 19p13, which spans the gene for tyrosine kinase 2 (TYK2) [148]; PSORS7 on chromosome 1p, which spans the gene for IL-23 receptor (IL-23R) [149].