NFKB1 and gout: The first step of nuclear factor kappa-B (NF-κB) activation is required to stimulate the expression of pro-IL-1β [11], and the maturation of IL-1β regulated by the NBD leucine-rich family (NLR) pyrin-containing 3 (NLRP3) inflammasome is the second key step in the initiation of gout flare [12].