RARA and breast cancer: By global gene expression microarray analysis, Rossetti et al. [23] determined that in breast cancer cells (T47DCtrl) grown under “physiological” RA culture conditions, many RARα-target genes, coding for tumor suppressor signaling pathways, as RARβ and the TGFβ-TGFβR2, are in a repressed transcriptional state marked by epigenetic histone modifications.