Assuming no overlap in the cohorts included in Table 1, 8 PCP genes (VANGL1-2, CELSR1-3, DVL3, SCRIB1 and PTK7) have been re-sequenced in a couple of hundred of CRS cases and no obvious loss of function (LoF) variant was identified in these genes in the majority of CRS cases analyzed. Here, PTK7 is linked to congenital rubella syndrome.