NLRP3 and inflammation: Finally, Madouri et al. demonstrated that mice deficient in NLRP3-/-, Casp-/-, or PYCARD-/- exhibited enhanced lung inflammation and pathology, including eosinophilic inflitration and Th2 cytokine release, upon exposure to HDM, supporting the notion that NLRP3 activation exerts protective functions against HDM-induced allergic lung inflammation [190].