Increased expression of NLRP3 and IL-1β was also detected in the sputum of patients with SA compared to MMA, and correlated with clinical parameters of disease, such as neutrophilic airway inflammation, Asthma Control Questionnaire (ACQ) score, and Forced Expiratory Volume in 1 second (FEV1)% [184]. Here, NLRP3 is linked to asthma.