NLRP3 and obesity due to melanocortin 4 receptor deficiency: Moreover, studies by Kim et al., in an experimental model of high fat diet-induced obesity, demonstrated that obese mice had increased AHR driven by aberrant NLRP3 inflammasome-dependent responses in the adipose tissue, which contributed to the activation of ILCs and increased IL-17 responses in the lung, in the absence of allergic sensitisation [182].