Furthermore, R70Q was considered a pretreatment predictor of posttreatment HCC, because the presence of R70Q at the start of antiviral therapy was associated with later HCC diagnosis, years after achieving SVR and eradication of HCV RNA, by use of Peg-IFN-plus-RBV or DAA therapy [34–37]. Here, IFNA1 is linked to hepatocellular carcinoma.