Among the most frequently mutated AD genes were germline pathogenic variants for conditions with variable expressivity and mild phenotypes (S2 Table), such as VWF (MIM:613160) involved in von Willebrand disease type 1, FLG (MIM:135940) involved in Ichthyosis vulgaris, PER3 (MIM:603427) involved in Advanced sleep phase syndrome type 3, as well as the cancer predisposition gene RANSEL involved in Prostate cancer 1 (MIM: 180435). This evidence concerns the gene PER3 and Alzheimer disease.