RYR1 and Hereditary breast cancer: Pathogenic variants in BRCA2 [hereditary breast cancer (MIM: 600185)], KCNH2 [Romano-Ward long-QT syndrome types 1, 2,and 3, Brugada syndrome (MIM: 600185)], MYBPC3 [Hypertrophic cardiomyopathy, dilated cardiomyopathy (MIM:600958)], LDLR Familial hypercholesterolemia (MIM: 143890)] and RYR1 [Malignant hyperthermia susceptibility (MIM: 145600)]were most prevalent, with a carrier rate of less than 1:700.