IGHG3 and Zika virus infectious disease: Cases were defined as having moderate evidence of maternal ZIKV infection if they had only one positive serologic test (i.e., IgM or IgG3) in pregnancy, an indication of seroconversion by PRNT50 during pregnancy (i.e., either a PRNT50 titer ≥1000 in pregnancy paired with a rise within 2 months post-pregnancy or 4-fold rise in PRNT50 titer from pregnancy to within 2 months post-pregnancy), or an equivocal PRNT50 test result in pregnancy paired with a positive PRNT50 within three months post-pregnancy (Fig 5).