SREBF1 and infection: As shown (S3B and S3C Fig), in HepG2 cells following Ad-TCF7L2DN infection, expression of genes that encode the 2 key lipogenic transcription factors—carbohydrate-responsive element-binding protein (ChREBP, Mlxipl) and sterol regulatory element-binding protein 1-c (SREBP-1c, srebf1)—were increased.