ME1 and infection: In MPH, Ad-TCF7L2DN infection also increased expression of both Mlxipl and Srebf1 (Fig 1K and 1L), accompanied by increased expression of hepatic genes that encode the 5 lipogenic enzymes (Fig 1M), known as acetyl-coA carboxylase (Acc1), enoyl-coA hydratase and 3-hydroxyacyl coA dehydrogenase (also known as peroxisomal L-bifunctional enzyme [Ehhadh]), fatty acid synthase (Fas), cytosolic malic enzyme 1 (Me1), and stearoyl-coA desaturase-1 (Scd1).