We also found that hepatic glycogen content in 12-week-old male LTCFND mice showed a trend of increase, whereas in mouse primary hepatocytes (MPHs), adenovirus Ad-TCF7L2DN infection but not Ad-TCF7L2 infection increased expression of glycogen synthase 2 (Gys2) (S2 Fig). The gene discussed is GYS2; the disease is infection.