In the current study, we observed elevated hepatic and plasma lipid contents in male LTCFDN mice, indicating the hepatic function of the Wnt signaling cascade or its effector β-cat/TCF on lipid homeostasis, in agreement with intensive studies on the implication of genetic mutations on the Wnt ligand coreceptor LRP6 in the susceptibility of dyslipidemia [30,59]. The gene discussed is LRP6; the disease is metabolic syndrome.