To demonstrate that the difference in PKC inhibitor responses in monocytes from FMF patients and HD was specifically due to MEFV mutation, we generated U937 cells expressing either WT MEFV or p.M694V MEFV. U937 were invalidated for the MEFV gene (Lagrange et al, 2018) to avoid any possible confounding factor and complemented with either 3xFLAG‐WT (Lagrange et al, 2018) or 3xFLAG‐p.M694V MEFV under the control of a doxycycline‐inducible promoter (Fig EV2A). This evidence concerns the gene PRRT2 and familial Mediterranean fever.