These stress‐related hormones are increased in patients with cancer and their contribution to tumor growth and disease progression has been established5 including in melanoma.6 Once activated by catecholamines, β‐AR stimulate several intracellular signal transduction pathways, such as the nitric oxide synthase, related to melanoma development and progression.7 Primary downstream effects include vasodilation and release of pro‐angiogenic factors, such as vascular endothelial growth factor (VEGF).5 This evidence concerns the gene ADRB2 and neoplasm.