High levels of PRINS expression in psoriatic non‐lesional keratinocytes led to alteration of the stress response in non‐lesional epidermis and contributed to psoriasis pathogenesis.81, 82 Mechanistically, PRINS may contribute to psoriasis by decreasing sensitivity to spontaneous keratinocyte apoptosis via the regulation of G1P3.81 Here, IFI6 is linked to psoriasis.