A major gap of knowledge in this field is related to the receptor mechanisms of the diverse biological functions of the CgA‐related polypeptides, with few exceptions regarding the direct interaction of human CgA with the integrin αv/β6 in the regulation of keratinocyte adhesion,204 CST with nicotinic acetylcholine receptors in the inhibition of catecholamine secretion by chromaffin cells,27, 31, 187, 188, 205, 206 and hCgA1–373 with neuropilin‐1 in angiogenesis and tumor growth stimulation. Here, CGA is linked to neoplasm.