CGA and neoplasm: Studies performed in mice have shown that endogenous murine CgA or exogenous recombinant hCgA1–439, but not the fragments lacking the C‐terminal region, can inhibit tumor growth in models of nonneuroendocrine solid‐tumors, including fibrosarcoma, mammary adenocarcinoma, Lewis lung carcinoma, and primary and metastatic melanoma.178 The inhibition of tumor growth is associated with reduction of microvessel density and blood flow in neoplastic tissues.