CFTR and metabolic disease: While an autosomal dominant inheritance pattern is the most common form of inheritance, another method of inheritance is in an autosomal recessive fashion whereby 2 mutated parental genes are needed for the phenotypic manifestation (e.g., CFTR gene and SPINK1).4 The autosomal recessive inheritance is a perplex pattern requiring environmental factors and genetic mutation or a mix of individual mutated genes.4 In the absence of known mutations, trauma, alcohol consumption, drug intake, infection, or metabolic disorders, it can be referred as idiopathic chronic pancreatitis.5