Active targeting of AuNPs with ligands to enable a high local accumulation in tumor tissues has been extensively investigated for non-invasive imaging and delivery of chemotherapeutics.40 Recently, there have been several studies demonstrating the potential utility of AuNPs to serve as radiosensitizers for tumors in different mouse models.10 In this study we utilize PSMA-targeted AuNPs and show significant active targeting of AuNPs within tumors expressing PSMA receptors. Here, FOLH1 is linked to neoplasm.