Although MPT0B390 strongly induced TIMP3 mRNA and protein expression, as well as apoptosis activation in HCT116 cells (Figure 1F-G and Figure 3B), our findings show that it did not inhibit tumor cell survival through TIMP3 induction according to the same viability in siRNA-mediated blockage of TIMP3 upregulation (Figure 3C-D). The gene discussed is TIMP3; the disease is neoplasm.