Synthesis and screening of N-1 sulfonamides 6,5 membered ring with N-hydroxyacrylamides (1-arylsulfonyl-5-(N-hydroxyacrylamide)azaindolines), which transcriptionally activate TIMP3 expression and lead to CRC cells apoptosis, as potential TIMP3 activators. Here, TIMP3 is linked to colorectal carcinoma.