TIMP3 expression also exhibited higher expression in normal tissues compared to cancerous region using bioinformatics analysis from the Gene Expression Omnibus (GEO) database (Figure 2 B, left panel), Gene Expression Profiling Interactive Analysis (GEPIA) (Figure 2B,) database (Figure 2B, right panel), and immunohistochemical staining in three clinical CRC patients' tissues (Figure 2C). This evidence concerns the gene TIMP3 and colorectal carcinoma.