Western blotting for TLR-4 showed that the expression of TLR-4 was significantly amplified in the BLM+HUMSCs (LD) and BLM+HUMSCs (HD) groups, indicating that transplantation of HUMSCs promotes the restoration of alveolar epithelial cells (Figure 8G). This evidence concerns the gene TLR4 and Bloom syndrome.