Intersecting the markers in the signatures established above with that data set (Fig. 6) revealed several comprised proteins as selectively secreted by one cell type, i.e., BCAM, GSTP1 and HSPA1A by tumor cells, CTSZ and TNFAIP6 by TAMs and LCK by TATs, while others originate from all cell types at similar levels (e.g., LAMA1, MMP16 or TAGLN2). This evidence concerns the gene MMP16 and neoplasm.