Analysis of the expression profiles of 404 breast cancer patients by integrating three available microarray datasets (GSE2034, GSE2603, GSE5327) obviously showed that these TFs were significantly co-expressed with ERα (co-expression coefficient=0.88) and other hormone receptors, such as the PR and AR, through unsupervised clustering analysis (Figure 5B). The gene discussed is ESR1; the disease is breast carcinoma.