Mechanistically, we provide direct evidence that BCAP31 may promote TNBC through its regulation of EGFR via oncogenic ligand-independent phosphorylation of the conserved regulatory tyrosine Y845 in the activation loop of the EGFR kinase domain 46, resulting in activation of AKT signalling and cancer development in TNBC (Figure 4). This evidence concerns the gene AKT1 and cancer.