Consistent with the essential role of PrPC and STI-1 in this regard, transplantation of LV-PrPC-sh-treated APSCs (LV-PrPC-sh-APSCs) or LV-STI-1-sh-treated APSCs (LV-STI-1-sh-APSCs) completely abolished the increase in neurite length and the increase in the number of neurite-bearing neurons compared to that of APSCs in stroke rats. Here, PRNP is linked to Stroke.