Increased expression of enzymes modifying extracellular matrix (ECM) by stromal cells results in increased collagen linearization and tissue rigidity in pre-malignant breast tissue 37, rigidity appears to favor tumoral progression 18, 33, while stroma remodeling enzymes such as LOX (Lysyl oxidase) favor metastasis and drug resistance in pancreatic cancer 38. Here, LOX is linked to pancreatic neoplasm.