LOX and familial pancreatic carcinoma: Increased expression of enzymes modifying extracellular matrix (ECM) by stromal cells results in increased collagen linearization and tissue rigidity in pre-malignant breast tissue 37, rigidity appears to favor tumoral progression 18, 33, while stroma remodeling enzymes such as LOX (Lysyl oxidase) favor metastasis and drug resistance in pancreatic cancer 38.