Th17 cells are a subset of T cells associated with many inflammatory and autoimmune diseases that secrete inflammatory factors such as IL-17 and IL-22 21-22.There is data showing that Th17 cells are closely related to the occurrence of renal ischemia-reperfusion injury, and its expression is significantly increased in ischemia-reperfusion tissues 23. The gene discussed is IL22; the disease is autoimmune disease.