In previous studies, we reported that tumor tissues of hepatocellular carcinoma and LUAD with high PRDX4 expression levels were significantly larger in size in comparison to those with low PRDX4 expression levels 21, 23, which was closely associated with the prognosis of these patients, suggesting that PRDX4 plays an important role in the proliferation of carcinoma cells. The gene discussed is PRDX4; the disease is hepatocellular carcinoma.